archetype (adl_version=1.4; uid=217e48d9-a3b5-48c5-bf7d-efef3c16b7b7)
	openEHR-EHR-CLUSTER.exam_blastocyst.v1

concept
	[at0000]	-- Examination of a blastocyst
language
	original_language = <[ISO_639-1::en]>
	translations = <
		["nb"] = <
			language = <[ISO_639-1::nb]>
			author = <
				["name"] = <"Peter Fedorcsak, Vebjørn Arntzen">
				["organisation"] = <"University of Oslo, Oslo University Hospital">
				["email"] = <"peterfe@uio.no, varntzen@ous-hf.no">
			>
		>
	>
description
	original_author = <
		["name"] = <"Peter Fedorcsak">
		["organisation"] = <"Oslo University Hospital">
		["email"] = <"peter.fedorcsak@medisin.uio.no">
		["date"] = <"2021-10-26">
	>
	details = <
		["nb"] = <
			language = <[ISO_639-1::nb]>
			purpose = <"For å registrere strukturerte observasjoner av en human blastocyst.">
			use = <"Brukes til å registrere morfologiske observasjoner av en human blastocyst , vanligvis som del av assistert befruktning.

Arketypen er laget spesifikt for å brukes i SLOT'et \"Undersøkelsesdetaljer\" i arketypen \"OBSERVATION.embryo_assessment\" eller \"ACTION.procedure\", men kan også brukes innen andre ENTRY- og CLUSTER-arketyper der det er klinisk passende.">
			keywords = <"in vitro, befruktning, IVF, reproduksjon, zygote, fertilisert, befruktet, egg, eggcelle, oocytt, embryo, blastocyst, assistert", ...>
			misuse = <"Skal ikke brukes til å registrere morfologiske observasjoner av oocytter, zygoter og embryoer i deling - bruk spesifikke CLUSTER arketyper.">
		>
		["en"] = <
			language = <[ISO_639-1::en]>
			purpose = <"To record structured observations about a human blastocyst.">
			use = <"Use to record morphological observations about a human blastocyst, usually as part of assisted reproduction treatment.

This archetype has been specifically designed to be used in the 'Observations detail' SLOT within the 'OBSERVATION.embryo_assessment' or 'ACTION.procedure' archetype, but can also be used within other ENTRY or CLUSTER archetypes, where clinically appropriate.">
			keywords = <"in vitro, fertilization, IVF, reproductive medicine, zygote, fertilised, fertilized, oocyte, egg, fertilisation, embryo, reproduction, ART, blastocyst", ...>
			misuse = <"Not to be used for recording observations on oocytes, zygotes and cleavage stage embryos - use specific CLUSTER archetypes for this purpose.">
			copyright = <"© openEHR Foundation">
		>
	>
	lifecycle_state = <"published">
	other_contributors = <"Vebjørn Arntzen, Oslo University Hospital, Norway (openEHR Editor)", "SB Bhattacharyya, Bhattacharyyas Clinical Records Research & Informatics LLP, India", "Peter Fedorcsak, University of Oslo, Norway (openEHR Editor)", "Rosane Gotardo, Systema Ltda., Brazil", "Heather Grain, Llewelyn Grain Informatics, Australia", "Gareth Greggains, Oslo University Hospital", "Liv Laugen, ​Oslo University Hospital, Norway, Norway (openEHR Editor)", "Heather Leslie, Atomica Informatics, Australia (openEHR Editor)", "Manisha Mantri, C-DAC, India", "Mikael Nyström, Cambio Healthcare Systems AB, Sweden", "Trine Skuland, Oslo University Hospital", "Norwegian Review Summary, Nasjonal IKT HF, Norway", "Julius Hreinsson, Laboratory Director at Reproductive Medicine, Sahlgrenska University Hospital, Sweden">
	other_details = <
		["licence"] = <"This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/4.0/.">
		["custodian_organisation"] = <"openEHR Foundation">
		["references"] = <"Alpha Scientists in Reproductive, M. and E.S.I.G.o. Embryology, The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction, 2011. 26(6): p. 1270-1283.

Hardarson, T., L. Van Landuyt, and G. Jones, The blastocyst. Human Reproduction, 2012. 27(suppl_1): p. i72-i91.">
		["original_namespace"] = <"org.openehr">
		["original_publisher"] = <"openEHR Foundation">
		["custodian_namespace"] = <"org.openehr">
		["MD5-CAM-1.0.1"] = <"25DE1CB79E30B209FCE47B998AFF3008">
		["build_uid"] = <"80f141a3-30aa-4a8d-a8b5-921a03bac275">
		["revision"] = <"1.0.1">
	>

definition
	CLUSTER[at0000] matches {    -- Examination of a blastocyst
		items cardinality matches {1..*; unordered} matches {
			ELEMENT[at0049] occurrences matches {0..1} matches {    -- Degree of expansion
				value matches {
					DV_CODED_TEXT matches {
						defining_code matches {
							[local::
							at0050,    -- Grade 1
							at0051,    -- Grade 2
							at0052,    -- Grade 3
							at0053,    -- Grade 4
							at0054,    -- Grade 5
							at0055]    -- Grade 6
						}
					}
					DV_TEXT matches {*}
				}
			}
			ELEMENT[at0056] occurrences matches {0..1} matches {    -- Inner cell mass morphology
				value matches {
					DV_CODED_TEXT matches {
						defining_code matches {
							[local::
							at0057,    -- A
							at0058,    -- B
							at0059,    -- C
							at0067]    -- Not accessible
						}
					}
					DV_TEXT matches {*}
				}
			}
			ELEMENT[at0060] occurrences matches {0..1} matches {    -- Trophectoderm morphology
				value matches {
					DV_CODED_TEXT matches {
						defining_code matches {
							[local::
							at0061,    -- A
							at0062,    -- B
							at0063]    -- C
						}
					}
					DV_TEXT matches {*}
				}
			}
			ELEMENT[at0064] occurrences matches {0..*} matches {    -- Other morphological features
				value matches {
					DV_TEXT matches {*}
				}
			}
			ELEMENT[at0068] occurrences matches {0..1} matches {    -- Morphology grade
				value matches {
					DV_TEXT matches {*}
				}
			}
		}
	}



ontology
	term_definitions = <
		["en"] = <
			items = <
				["at0000"] = <
					text = <"Examination of a blastocyst">
					description = <"Morphological findings obtained by microscopy of a human blastocyst.">
				>
				["at0049"] = <
					text = <"Degree of expansion">
					description = <"Degree of expansion of the blastocyst.">
				>
				["at0050"] = <
					text = <"Grade 1">
					description = <"The blastocoel cavity is less than the half of the embryo volume.">
				>
				["at0051"] = <
					text = <"Grade 2">
					description = <"The blastocoel cavity is > 50% of the embryo volume.">
				>
				["at0052"] = <
					text = <"Grade 3">
					description = <"The blastocoel cavity completely fills the embryo volume.">
				>
				["at0053"] = <
					text = <"Grade 4">
					description = <"The blastocoel cavity is larger than the original volume of the embryo, thinned zona pellucida.">
				>
				["at0054"] = <
					text = <"Grade 5">
					description = <"Hatching blastocyst.">
				>
				["at0055"] = <
					text = <"Grade 6">
					description = <"Completely hatched blastocyst.">
				>
				["at0056"] = <
					text = <"Inner cell mass morphology">
					description = <"Morphology of the inner cell mass.">
				>
				["at0057"] = <
					text = <"A">
					description = <"The inner call mass contains many tightly packed cells.">
				>
				["at0058"] = <
					text = <"B">
					description = <"The inner call mass contains several loosely grouped cells.">
				>
				["at0059"] = <
					text = <"C">
					description = <"The inner call mass contains few loosely bound cells.">
				>
				["at0060"] = <
					text = <"Trophectoderm morphology">
					description = <"Morphology of the trophectoderm of the blastocyst.">
				>
				["at0061"] = <
					text = <"A">
					description = <"Trophectoderm contains many cells that form a cohesive epithelium.">
				>
				["at0062"] = <
					text = <"B">
					description = <"Trophectoderm contains few cells that form a loose epithelium.">
				>
				["at0063"] = <
					text = <"C">
					description = <"Trophectoderm contains very few large cells that struggle to form a cohesive epithelium.">
				>
				["at0064"] = <
					text = <"Other morphological features">
					description = <"Additional morphological features of the blastocyst not captured by specific parameters.">
					comment = <"For example: signs of degeneration, such as presence of necrosis and exclusion of cells; cellular bridges, vacuolation; or multiple hatching points. The occurrences for this data element is set to 0..* to allow for more than one morphological attribute to be added as a coded value.">
				>
				["at0067"] = <
					text = <"Not accessible">
					description = <"Inner cell mass morphology is not accessible.">
				>
				["at0068"] = <
					text = <"Morphology grade">
					description = <"Overall grading or score based on recorded morphological features of the blastocyst.">
					comment = <"Use of an established morphology assessment classification is preferred.">
				>
			>
		>
		["nb"] = <
			items = <
				["at0000"] = <
					text = <"Undersøkelse av en blastocyst">
					description = <"Morfologiske funn ved mikroskopisk undersøkelse av en human blastocyst.">
				>
				["at0049"] = <
					text = <"Ekspanderingsgrad">
					description = <"Grad av ekspandering i blastocysten.">
				>
				["at0050"] = <
					text = <"Grad 1">
					description = <"Blastocystkaviteten opptar mindre enn halvparten av blastocystens volum.">
				>
				["at0051"] = <
					text = <"Grad 2">
					description = <"Blastocystkaviteten opptar > 50% av blastocystens volum.">
				>
				["at0052"] = <
					text = <"Grad 3">
					description = <"Blastocystkaviteten fyller blastocystens hele volum.">
				>
				["at0053"] = <
					text = <"Grad 4">
					description = <"Blastocystkaviteten er større enn blastocystens opprinnelig volum, og zona pellucida har blitt tynnere.">
				>
				["at0054"] = <
					text = <"Grad 5">
					description = <"Klekkende blastocyst, celler er på vei at av zona pellucida.">
				>
				["at0055"] = <
					text = <"Grad 6">
					description = <"Fullstendig klekket blastocyst, hele blastocysten har kommet ut av sona pellucida.">
				>
				["at0056"] = <
					text = <"Morfologi av den indre cellemassen">
					description = <"Morfologi av den indre cellemassen.">
				>
				["at0057"] = <
					text = <"A">
					description = <"Den indre cellemasse består av mange, tett pakkede celler.">
				>
				["at0058"] = <
					text = <"B">
					description = <"Den indre cellemasse består av flere, løst grupperte celler.">
				>
				["at0059"] = <
					text = <"C">
					description = <"Den indre cellemasse består av få, løst tilknyttede celler.">
				>
				["at0060"] = <
					text = <"Morfologi av trofektodermen">
					description = <"Morfologi av blastocystens trofektoderm.">
				>
				["at0061"] = <
					text = <"A">
					description = <"Trofektodermen består av flere celler som danner et sammenhengende epitel.">
				>
				["at0062"] = <
					text = <"B">
					description = <"Trofektodermen består av få celler som danner et løst epitel.">
				>
				["at0063"] = <
					text = <"C">
					description = <"Trofektodermen består av få, veldig store celler som knapt danner et sammenhengende epitel.">
				>
				["at0064"] = <
					text = <"Andre morfologiske observasjoner">
					description = <"Ytterligere morfologiske observasjoner av blastocysten som ikke dekkes av de andre spesifiserte elementene.">
					comment = <"Kan brukes til å beskrive for eksempel tegn til degenerering, slik som nekrose og utstøtelse av celler, cellulære broer, vakuoler og flere klekkingspunkter. Dette dataelementet er satt til å kunne repeteres fordi det kan være flere observasjoner, både fritekst og kodede.">
				>
				["at0067"] = <
					text = <"Utilgjengelig">
					description = <"Den indre cellemassen kan ikke vurderes.">
				>
				["at0068"] = <
					text = <"Morfologisk gradering">
					description = <"Overordnet gradering eller skår basert på blastocystens registrerte, morfologiske egenskaper.">
					comment = <"Bruk av en etablert skala for vurdering av blastocystens morfologi anbefales.">
				>
			>
		>
	>